Association between Asp299Gly and Thr399Ile Polymorphisms in Toll-Like Receptor 4 Gene and Type 2 Diabetes Mellitus: Case-Control Study and Meta-Analysis
نویسندگان
چکیده
Taís Silveira Assmann1,2, Natália Emerim Lemos1,2, Letícia de Almeida Brondani1,2, Rodrigo Carlessi1,2, Carmen Maldonado-Bernal3,4, Miguel Cruz3,4, Luis Henrique Canani1,2 and Daisy Crispim1,2* 1Endocrine Division, Hospital de Clínicas de Porto Alegre. Porto Alegre, Rio Grande do Sul, Brazil 2Postgraduate Program in Medical Sciences: Endocrinology, Universidade Federal do Rio Grande do Sul. Porto Alegre, Rio Grande do Sul, Brazil 3Research Laboratory in Immunology and Proteomics, Hospital Infantil de México Federico Gómez, Mexico City, México 4Biochemistry Research Unit, Hospital de Especialidades, Centro Médico Nacional SXXI, IMSS, México City, México
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Interleukin-17 Serum Levels and TLR4 Polymorphisms in Ulcerative Colitis
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OBJECTIVE To establish whether single nucleotide polymorphisms (Asp299Gly and Thr399Ile) of the toll-like receptor 4 have an association with late diabetic complications. RESEARCH DESIGN AND METHODS The study was conducted in 246 type 1 and 530 type 2 diabetic patients. The alleles of both polymorphisms were detected using PCR and subsequent cleavage by NcoI and HinfI restriction endonuclease...
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OBJECTIVE The objective of this study was to establish the role of the TLR-4 gene polymorphisms in individuals in risk of developing ACS. METHODS The study included 457 Mexican patients with ACS and 283 control individuals. The TLR-4 Asp299Gly and TLR-4 Thr399Ile single nucleotide polymorphisms were genotyped using 5' exonuclease TaqMan genotyping assays on an 7900HT Fast real-time PCR system...
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BACKGROUND The pathogenesis of inflammatory bowel disease (IBD) involves interactions between the host genetic susceptibility, intestinal microflora and mucosal immune responses through the pattern recognition receptor. Polymorphisms in toll-like receptor 4 (TLR4) induce an aberrant immune response to indigenous intestinal flora, which might favor IBD development. In this study, we aimed to det...
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PURPOSE Activation of the innate immune system and chronic low-grade inflammation are thought to be involved in the pathogenesis of atherosclerosis and also thought to be associated with type 2 diabetes and its complications. As a receptor for bacterial lipopolysaccharide and heat-shock proteins, Toll-like receptor 4 (TLR4) is one of the central regulators of the immune response. Recent studies...
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